What Melanotan I is
Melanotan I (MT1) is a synthetic 13-residue analog of α-melanocyte-stimulating hormone (α-MSH), also written [Nle4, D-Phe7]-α-MSH or NDP-α-MSH. It keeps the full linear α-MSH sequence, acetylated at the N-terminus and amidated at the C-terminus, with two substitutions: norleucine replaces methionine at position 4, removing the oxidation-prone sulfur, and D-phenylalanine replaces L-phenylalanine at position 7, which makes the core of the molecule more resistant to enzymes and increases its affinity for the melanocortin 1 receptor (MC1R).
MT1 Labs supplies Melanotan I as a lyophilized powder in 10 mg vials. Each lot is tested by ILS Laboratories for HPLC purity, identity against a reference standard and net content, with a fentanyl screen, and the certificate is published here before sale through Klow.bio.
MT1 is a linear peptide and a different compound from Melanotan II (MT2), which is a shorter, cyclic analog. The two have different formulas and molecular weights (1646.85 vs 1024.18 g/mol).
Structure
MT1 is linear, with an acetylated N-terminus (Ac-Ser1) and amidated C-terminus (Val13-NH2). Position 4 is norleucine (Nle) and position 7 is D-phenylalanine. The central His-D-Phe-Arg-Trp segment is the core shared by melanocortin receptor ligands. The single tryptophan (Trp9) is its most oxidation-sensitive residue.
complete MT1 specifications.
Storage and handling
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.